TIMP-1; Human Neutrophil Granulocyte

Biochem/physiol Actions

Cell permeable: no

Reversible: no

Product does not compete with ATP.

Primary TargetMMP activity

General description

Native TIMP-1 from human granulocyte. Member of a family of inhibitors that participate in the activation and regulation of MMP activity. Forms a non-covalent stoichiometric complex with latent and active MMPs. Binds to pro-MMP-9 and MMP-9 via their C-terminal domains.

Native TIMP-1 from human granulocyte. Member of a family of inhibitors that participate in the activation and regulation of MMP activity. Forms a non-covalent stochiometric complex with latent and active MMPs. Binds to pro-MMP-9 and MMP-9 via their C-terminal domains.

Legal Information

Brij is a registered trademark of Croda International PLC

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Kolkenbrock, H., et al. 1996. Biol. Chem. 377, 529.Kolkenbrock, H., et al. 1995. Biol. Chem. Hoppe Seyler 376, 495.

Packaging

5 µg in Plastic ampoule

Please refer to vial label for lot-specific concentration.

Physical form

In 200 mM NaCl, 50 mM Tris-HCl, 5 mM CaCl₂, 1 µM ZnCl₂, 0.05% BRIJ^® 35 Detergent, 0.05% NaN₃, pH 7.0.

Preparation Note

Prepared from stimulated neutrophils that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Reconstitution

Following initial thaw, aliquot and freeze (-70°C).

Warning

Toxicity: Standard Handling (A)